its been some months since i've ever started to experience this problem.Sometimes, i think mostly when i change maps, mouse clicks go unfunctional and i loose the control of my character.To fix that, i go tabbed, and full screen again.Or, if i'm playing on windowed mode, clicking on the Ro symbol at the task bar fixes it.
Its really really annoying,mostly because it is random and unexpected..sometimes causing deaths during instance runs..
What do i need to fix this permenantly?