Hello, this is a weird one. I have the Logitech G910 keyboard with the latest firmware.
The keyboard has dedicated media controls including a volume wheel.
When opening the Transcendence launcher the volume wheel still works but as soon as the game window launches it no longer functions.
The issue lasts as long as the game is open and continues even if minimized or alt-tabbed into another window.
I've tested with the iRO launcher and game window but could not duplicate the problem.
I was, however, able to duplicate the issue with Transcendence again on a laptop that also has built in dedicated volume controls.