Make a 150/50 Genetic and Sura. Duel client the two. Use the Sura to tank and the Genetic to kill. You can kill almost all the MvP's with this setup with crap gears. Only real expense is acid bombs. If you want to kill all the MvP's efficiently(ifrit, fallen bishop, bee, gloom, thanatos, ect...), you will need to upgrade the crap gear to good gear lol.
This is the method I use. I have been lucky enough to get a Mistress Card, Golden Thief Bug Card, Stormy Knight Card, Ifrit Card, and just got a Pharaoh Card.
Right now Genetic is the BEST MvP class. Can kill every mvp. Has crazy good homunculus skills depending on the one you choose. Pretty darn easy to level to 150/50. I would say start with that character first and then work on your Sura. They are both pretty good PvP/WoE characters as well.